Thanks to advancements in regenerative medicine, signs of aging and skin damage can now be treated using your own cells. Autologous Fibroblast Culture Therapy involves growing a person’s own fibroblast cells in a laboratory and injecting them back into the skin for skin rejuvenation, wrinkle reduction, and tissue regeneration.
This method is a completely natural and biological anti-aging treatment that promotes long-term skin rejuvenation and rejuvenation.
HOW DOES AUTOLOGOUS FIBROBLAST CULTURE TREATMENT WORK?
Fibroblasts are the main cells found in the dermis layer and are responsible for producing essential connective tissue components such as collagen, elastin and hyaluronic acid.
This treatment follows the steps below:
1️⃣ COLLECTION OF FIBROBLAST CELLS
A small skin biopsy with a diameter of 1-2 mm is taken from behind the ear.
2️⃣ CULTIVATION OF CELLS IN THE LABORATORY
Fibroblasts are multiplied in specialized biotechnological laboratories for 4–8 weeks.
✔ Millions of young fibroblast cells are produced during this period.
✔ Since they are completely derived from the patient’s own cells, there is no risk of allergic reaction.
3️⃣ INJECTION OF FIBROBLASTS INTO THE SKIN
The cultivated fibroblasts are injected under the skin using micro-needles.
✔ Collagen and elastin production restarts.
✔ Cellular regeneration accelerates.
✔ Skin tone becomes more even and radiant.
BENEFITS OF AUTOLOGOUS FIBROBLAST CULTURE TREATMENT
✅ A completely natural and personalized treatment
✅ Increases collagen and elastin production, tightening the skin
✅ Reduces wrinkles and fine lines
✅ Evens out skin tone and lightens pigmentation
✅ Improves acne scars and wound scars
✅ Minimal downtime with a natural rejuvenation effect
✅ Long-lasting and effective rejuvenation
DOES IT PROVIDE A NATURAL LOOK?
Yes! Autologous fibroblast culture treatment activates the skin’s natural renewal mechanisms, so it does not create an artificial appearance.
The skin appears brighter, firmer, younger and healthier while maintaining its natural expression.
WHO IS IT SUITABLE FOR?
✔ Those who want to reduce wrinkles and loss of elasticity
✔ Individuals seeking firmer and younger-looking skin
✔ Those with uneven skin tone, spots or scars
✔ Individuals with under-eye bags or dark circles
✔ Those looking for a natural and long-term rejuvenation method
⚠ Who is it NOT suitable for?
Although autologous fibroblast treatment is biologically safe and effective, it may not be appropriate for some individuals. It is not applied in the following cases:
• Active skin infections (herpes, bacterial infections)
• Uncontrolled autoimmune diseases (e.g., lupus, scleroderma)
• Active cancer diagnosis
• Pregnancy and breastfeeding (due to limited human studies)
• Skin diseases or systemic conditions preventing biopsy
• Patients on immunosuppressive therapy
• Severe diabetic patients with impaired wound healing
Since this treatment is highly personalized, each patient must undergo a detailed dermatological assessment.
WHICH AREAS CAN BE TREATED?
1. Face
• Forehead lines
• Glabella (frown lines)
• Temples
• Eye area (crow’s feet, under-eye wrinkles)
• Cheeks (volume loss, acne scars)
• Nasolabial folds
• Upper lip lines
• Jawline and marionette lines
2. Neck and Décolletage
• Neck lines
• Mild sagging under the chin
• Fine lines and pigmentation in the décolleté
3. Hands
• Loss of volume and visible veins
• Fine lines and thinning skin
4. Local Scar and Tissue Damage
• Acne scars
• Wound scars
• Sun-damaged local areas
• Local depressions from previous injections
5. Body (selected indications)
• Abdomen and inner arms: mild sagging and fine wrinkles
• Above the knees and inner thighs: areas with collagen loss
(Note: These applications are performed based on medical evaluation.)
Fibroblast treatment can be applied not only to the face but to any area requiring collagen support. This biological treatment targets the skin’s potential, not its chronological age.
WHEN ARE RESULTS VISIBLE?
✔ A slight glow is noticeable after the first session.
✔ Collagen production increases significantly within 4–6 weeks.
✔ Full results reach maximum effect in 3–6 months.
HOW LONG DOES IT LAST?
✔ The effect of autologous fibroblast treatment can last 2–4 years.
✔ Due to natural aging, a maintenance session is recommended after 2–3 years.
IS ONE SESSION ENOUGH, OR ARE MULTIPLE SESSIONS NEEDED?
✔ Usually 2–3 sessions spaced 4 weeks apart are recommended.
✔ Clinical reassessment every 6 months is helpful for optimal results.
HOW LONG DOES THE PROCEDURE TAKE?
💉 Approximately 30–45 minutes.
IS IT PAINFUL?
No, apart from a mild stinging sensation, it is not painful.
A topical anesthetic cream is applied beforehand.
POST-PROCEDURE CARE
After autologous fibroblast injection, it takes time for the cells to integrate into the tissue and stimulate collagen synthesis. Therefore, all external factors that could harm skin physiology should be avoided in the first 7 days.
The recommendations below are based on international cellular therapy protocols and clinical guidelines:
Within the First 24 Hours:
• Do not wash, rub or apply makeup to the treated area.
(Source: Dermatol Surg. 2015;41(8):933–940)
• Avoid topical acids, retinoids, alcohol-containing products and essential oils.
• Cold application is not recommended unless needed, as low temperature may suppress fibroblast metabolism.
(Source: Int J Mol Sci. 2020;21(16):5814)
Within the First 48 Hours:
• Avoid heavy exercise, sauna, hammam and steam baths.
• Sun protection is critical.
Apply SPF 50+ broad-spectrum sunscreen twice daily.
(UV exposure suppresses fibroblast function.)
(Source: J Invest Dermatol. 2009;129(7):1752–1760)
Within the First 7 Days:
• Avoid exfoliating or irritating treatments (peels, dermaroller, laser).
(Source: J Cosmet Dermatol. 2021;20(2):437–445)
• Support the moisture barrier.
• Use barrier-repair moisturizers with ceramides, cholesterol and fatty acids.
(Source: J Drugs Dermatol. 2014;13(4):478–484)
• Adequate sleep and hydration support fibroblast integration and collagen synthesis.
(Source: Sleep Health. 2015;1(2):89–96)
Additional Note:
Fibroblast culture injections do not trigger immune response during recovery, but external interventions may reduce cellular activity. All non-medical applications should be avoided.
IS THE PROCEDURE SAFE?
Yes.
Since the patient’s own cells are used, there is no risk of immune reaction.
Cells are produced under sterile conditions compliant with GMP standards.
ARE THERE ANY SIDE EFFECTS?
Side effects are rare.
• Temporary sensitivity at the biopsy site
• Mild redness or swelling at the injection area
CAN IT BE APPLIED TO EVERYONE?
No.
The treatment must be planned after medical evaluation.
Special caution is needed in individuals with connective tissue diseases or active systemic conditions.
IS REDNESS, BRUISING OR SWELLING EXPECTED AFTER THE PROCEDURE?
Mild redness or bruising may rarely occur.
These usually resolve within a few days.
DOES IT REQUIRE EXTRA CARE?
Not mandatory. However:
• Barrier-protective moisturizers
• Sunscreen
• Antioxidants such as vitamin C may enhance results.
IS REGULAR MAINTENANCE NECESSARY?
Not mandatory, but an annual session is recommended to slow aging and maintain skin quality.
Regular sessions help decrease biological aging speed.
IN SUMMARY, AUTOLOGOUS FIBROBLAST CULTURE TREATMENT…
✔ Is a completely natural, biological and personalized rejuvenation method
✔ Offers long-term and lasting results
✔ Provides skin tightening and rejuvenation
✔ Is safe, innovative and effective
✨ The most natural way to rejuvenate with your own cells: Autologous Fibroblast Culture Treatment! ✨